Platelet-clumping substance-its structure and role

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APPEARANCE OF PLATELET - CLUMPING SUBSTANCE 349 Appearance of Platelet - Clumping Substance After Acidification of Heparinized Plasma of Rabbit

I T IS WELL DOCUMENTED that platelet-thrombi are found during some inflammatory processes, but the exact mechanisms involved are still unknown. The authors demonstrated’3 the appearance of platelet-clumping substance in heparinized rabbit plasma and a concomitant decrease in the circulating platelet count after the intravenous injection of high molecular weight substances such as bacterial endo...

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Acid mucopolysaccharides as cofactor in formation of platelet-clumping substance.

Incubation at 37#{176}Cfor 30 mm or the addition of CaCl2 (5 mM) generated platelet-clumping activity in citrated plasma and EDTA plasma previously acidified to pH 5.5 and in which heparin was added to give a concentration of 0.5 mg/mi. Similar treatment could not produce platelet-clumping activity in saline or denatured plasma that had been heated to 56#{176}C.Heparin, chondroitin sulfate B, o...

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Acid Mucopolysaccharides As Cofactor in Formation of Platelet - clumping Substance

Incubation at 37#{176}Cfor 30 mm or the addition of CaCl2 (5 mM) generated platelet-clumping activity in citrated plasma and EDTA plasma previously acidified to pH 5.5 and in which heparin was added to give a concentration of 0.5 mg/mi. Similar treatment could not produce platelet-clumping activity in saline or denatured plasma that had been heated to 56#{176}C.Heparin, chondroitin sulfate B, o...

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Chromatographic and electrophoretic separation of platelet-clumping substance in rabbit plasma.

The authors previously reported that platelet-clumping substance (SHIMAMOTO and YAMAZAKI, 1958)1) was detected in heparinized plasma from rabbits administered adrenaline or high molecular weight substance such as agar solution and bacterial endotoxin by an intravenous injection.2) The plateletclumping substance also came to be observed in vitro of ter weak acidification of plasma in the presenc...

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Structure: Its Shadow and Substance

Structural realism as developed by John Worrall and others can claim philosophical roots as far back as the late 19th century, though the discussion at that time does not unambiguously favor the contemporary form, or even its realism. After a critical examination of some aspects of the historical background some severe critical challenges to both Worrall’s and Ladyman’s versions are highlighted...

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ژورنال

عنوان ژورنال: Ensho

سال: 1982

ISSN: 0389-4290,1884-4006

DOI: 10.2492/jsir1981.2.4_387